Adverse reaction Severity* Modification

Stomatitis

Stomatitis
Grade 2 or 3



  • Withhold FYARRO until Grade ≤1
  • Restart at the same dose for first occurrence
  • If recurs, restart at reduced dose level
Grade 4
  • Permanently discontinue FYARRO

Anemia

Anemia
Grade 2

  • Withhold FYARRO until Hb ≥8 g/dL
  • Restart at the same dose level
Grade ≥3
  • Withhold FYARRO until Hb ≥8g/dL
  • Restart at the same dose level
  • If recurs, resume at reduced dose level

Thrombocytopenia

Thrombocytopenia
Grade 2


  • Withhold FYARRO until platelet count >100x109/L
  • Restart at the same dose level
Grade ≥3
  • Withhold FYARRO until platelet count >100x109/L
  • Restart at reduced dose level

Neutropenia

Neutropenia
Grade 2 or 3


  • Withhold FYARRO until absolute neutrophil count ≥1.5x109/L
  • Restart at the same dose level
Grade 4
  • Withhold FYARRO until absolute neutrophil count ≥1.5x109/L
  • Restart at reduced dose level

Infections

Infections
Grade 3


  • Withhold FYARRO until resolved
  • Restart at reduced dose level
  • If recurs, permanently discontinue FYARRO
Grade 4
  • Withhold FYARRO until resolved
  • Restart at reduced dose level or permanently discontinue FYARRO

Hypokalemia

Hypokalemia
Grade 2


  • Withhold FYARRO until Grade ≤1
  • Restart at the same dose level
  • If recurs, restart at reduced dose level
Grade ≥3
  • Withhold FYARRO until Grade ≤1
  • Restart at reduced dose level
  • If recurs, permanently discontinue FYARRO

Hyperglycemia

Hyperglycemia
Grade ≥3

  • Withhold FYARRO until Grade ≤2
  • Restart at reduced dose level

Interstitial lung
disease/noninfectious
pneumonitis

Interstitial lung disease/noninfectious pneumonitis
Grade 2






  • Withhold FYARRO for up to 3 weeks until Grade ≤1
  • Restart at reduced dose level
  • If not resolved to Grade ≤1 within 3 weeks, permanently discontinue FYARRO
  • If recurs, permanently discontinue FYARRO
Grade ≥3
  • Permanently discontinue FYARRO

Hemorrhage

Hemorrhage
Grade 2 or 3


  • Withhold FYARRO until Grade ≤1
  • Resume at reduced dose
  • If recurs, permanently discontinue FYARRO
Grade 4
  • Permanently discontinue FYARRO

Other adverse reactions

Other adverse reactions
Grade 3


  • Withhold FYARRO until Grade ≤1
  • Restart at the same dose level
  • If recurs, restart at reduced dose level
Grade 4
  • Permanently discontinue FYARRO

*

Severity based on NCI Common Terminology Criteria for Adverse Events Version 4.03.